The team created a range of fully synthetic dendritic polymer-based universal heparin reversal agents (UHRAs). They described their results in Science Translational Medicine. With all this in mind, Jayachandran Kizhakkedathu, PhD, of the University of British Columbia in Vancouver, and his colleagues set out to create a safe, synthetic antidote that works with all heparins used in clinics today. None of the available, synthetically made reversal drugs work with all varieties of heparins, and they are relatively toxic, with toxicity varying from person to person. Researchers say they’ve developed a synthetic molecule that can reverse the effects of all heparin products, both in vitro and in vivo.įinding a drug to reverse the anticoagulant effect of heparin is complicated because there are about a dozen approved heparin products on the market.
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